Good Article in the Wall Street Journal regarding High-Tech companies locating in Midwest cities.  The article focused on Ohio but Kentucky could as well have been mentioned.  They key takeaways is that the companies relocate for: Cost of Doing Business Availability of grant programs and tax breaks One area that was not mentioned but in my expereience plays a big role as well is quality of Life in the midwest. There still are challenges in terms of getting the follow-on funding and in Kentucky one challenge is the lack of sufficient seed stage lead investors.